Job Description Summary
The department of Biochemistry & Molecular Biology at MUSC has an opening for a highly motivated and collegial Postdoctoral Fellow in the laboratory of Dr. Judit Jimenez Sainz. The Jimenez Sainz lab focuses on the Breast Cancer Susceptible Gene 1/2 (BRCA1/2) and the Partner and localizer of BRCA2 (PALB2), caretakers of genome integrity which mutated lead to high risk of breast, ovarian, prostate, pancreatic and melanoma cancers. BRCA1/2 and PALB2 are fundamental players in the repair of double strand breaks through its role in homologous recombination and replication to preserve DNA stability. Specifically, the lab is seeking to understand the impact of genetic variants in BRCA1/2 and PALB2 localization and functions to define cancer risk and response to therapy. A second goal of the Jimenez Sainz lab is to identify novel therapeutic strategies to sensitize tumor cells based on cellular mislocalization of BRCA1/2 and RAD51 (BRCA2 partner in homologous recombination). The third goal of the Jimenez Sainz lab is to define the factors involved in the crosstalk between homologous recombination and replication machineries upon platinum drugs and PARP inhibitors.Entity
Medical University of South Carolina (MUSC - Univ)Worker Type
EmployeeWorker Sub-Type?
RegularCost Center
CC000952 COM BIOCHEM Administration CCPay Rate Type
SalaryPay Grade
University-00
Pay Range
$0 - $0 - $0Scheduled Weekly Hours
40Work Shift
Job Description
Minimum Experience and Training Requirements:
PhD in Biochemistry, Molecular and Cellular Biology, genetics or related field related techniques Human cell and tissue culture, standard DNA, protein electrophoresis techniques and microscopy
Additional Knowledge, skill, ability preferred:
Required experience in biochemistry, molecular and cellular biology related techniques Required experience with human cells and tissue culture, standard DNA, protein electrophoresis techniques and microscopy.
Must have the ability to think creatively and work independently as well as part of the team. Organizational skills, Verbal and written communication skills, Track record of publications and Excellent interpersonal skills
Job Duties:
1) Collaborates with the PI and other lab members involved to design and executes experiments using state-of-the-art biochemistry, molecular biology and human cells to study the functionality and pathogeneicity of the BRCA1/2 and PALB2 genetic variants to define cancer risk and response to therapy. These duties involved included protein purification, radioactive labeling of oligonucleotides, in vitro DNA strand exchange, cellular localization analysis in live and fixed cells, DNA damage assays, homologous recombination reporters, DNA fiber experiments, clonogenic assays, cell culture, molecular and functional experiments.
30% of total effort
2) Collaborates in collecting and analyzing data generated from the experiments and Duties include keeping accurate records on a daily basis, identifying and using appropriate software for analysis of data, collaborating with Biostatistics and Bioinformatics Research Shared Resources to insure quality of the results, interpreting results and planning new experiments,
30% of total effort
3) Collaborates in preparing manuscripts and grants based on the experimental data generated. Duties include keeping current with the literature, preparing figures based on data collected, writing manuscripts and sections of grants with the PI and senior team members, presenting current work in research in progress seminars, attending departmental seminars and participating in journal clubs.
30% of total effort
4) Helps with laboratory maintenance and regulatory compliance, eg ordering, cleanup of lab areas, maintenance of equipment, helping to prepare IACUC protocols and amendments when appropriate 10% of total effort
MUSC Physical Requirements:
(Note: The following descriptions are applicable to this section: Continuous - 6-8 hours per shift; Frequent - 2-6 hours per shift; Infrequent - 0-2 hours per shift)
Ability to perform job functions in an upright position. (Frequent)
Ability to perform job functions in a seated position. (Continuous)
Ability to perform job functions while walking/mobile. (Frequent)
Ability to climb, using step stool. (Infrequent)
Ability to work in temperature extremes (32° F to 100° F) when required due to assignments in cold rooms and/or foreign countries. (Infrequent)
Ability to work in confined/cramped spaces. (Continuous)
Ability to bend at the waist. (Frequent)
Ability to twist at the waist. (Frequent)
Ability to fully use both hands/arms. (Continuous)
Ability to perform repetitive motions with hands/wrists/elbows and shoulders. (Frequent)
Ability to fully use both legs. (Frequent)
Ability to reach in all directions, stretch, bend, while moving items/materials from both sitting and standing positions. (Frequent)
Ability to maintain good olfactory sensory function/distinction. (Continuous)
Ability to lift materials up to 20 lbs., unassisted. (Infrequent)
Ability to lift and carry 4 liter waste material bottles a distance of 30 feet, unassisted. (Frequent)
Ability to lift and carry 25-30 lbs. jugs of liquid a distance of 100 feet, unassisted. (Infrequent)
Ability to lift file boxes, from floor level to counter tops, unassisted. (Frequent) Ability to push/
Ability to lift 40 lbs. centrifuge rotors from floor level to height of 40 inches, then down 20 inches into centrifuge drum, unassisted. (Infrequent)
Ability to lift 25 lbs. boxes, from floor level to maximum height of 72 inches, unassisted. (Infrequent)
Ability to push/pull file boxes from one location to another at floor level. (Frequent)
Ability to maneuver heavy equipment on bench tops, 50 lbs. or greater, unassisted. (Frequent)
Ability to perform gross motor functions with frequent fine motor movements. (Continuous)
Ability to maintain 20/40 vision, corrected, in one eye or with both eyes. (Continuous)
Ability to match or discriminate between colors, normally. (Continuous)
Ability to hear and recognize various alarms emitting from work area systems. (Continuous)
Ability to hear and/or understand conversations. (Continuous)
Ability to work in a darkroom for processing film, etc. (Continuous)
Ability to be qualified physically for respirator use, initially and annually. (Continuous)
Additional New Requirements:
Ability to work rotating shifts as required.
Ability to work overtime as required.
Ability to learn and use new processes, tools and equipment as required.
Additional Job Description
Physical Requirements: (Note: The following descriptions are applicable to this section: Continuous - 6-8 hours per shift; Frequent - 2-6 hours per shift; Infrequent - 0-2 hours per shift) Ability to perform job functions in an upright position. (Continuous) Ability to perform job functions in a seated position. (Continuous) Ability to perform job functions while walking/mobile. (Frequent) Ability to climb stairs. (Infrequent) Ability to work indoors. (Continuous) Ability to work in all cold temperature extremes, i.e. spot coolers. (Frequent) Ability to bend at the waist. (Frequent) Ability to twist at the waist. (Frequent) Ability to perform 'pinching' operations. (Continuous) Ability to fully use both hands/arms. (Continuous) Ability to perform repetitive motions with hands/wrists/elbows and shoulders. (Continuous) Ability to fully use both legs. (Continuous) Ability to reach in all directions. (Continuous) Possess good finger dexterity. (Continuous) Ability to maintain tactile sensory functions. (Continuous) Ability to maintain good olfactory sensory function. (Continuous) Ability to lift and carry 15 lbs., unassisted. (Frequent) Ability to lift objects, up to 15 lbs., from floor level to height of 72 inches, unassisted. (Frequent) Ability to lower objects, up to 15 lbs., from height of 72 inches to floor level, unassisted. (Frequent) Ability to push/pull objects, up to 15 lbs., unassisted. (Infrequent) Ability to lift and carry objects up to 15 lbs. a distance of five (5) floors and to outlying buildings. (Frequent) Ability to maintain 20/40 vision, corrected. (Continuous) Ability to see and recognize objects close at hand. (Continuous) Ability to see and recognize objects at a distance. (Continuous) Ability to match or discriminate between colors. (Continuous) Ability to determine distance/relationship between objects; depth perception. (Continuous) Good peripheral vision capabilities. (Continuous) Ability to maintain hearing acuity, with correction. (Continuous) Ability to perform gross motor functions with frequent fine motor movements. (Continuous) Ability to be qualified physically (by medical personnel) for respirator use, initially and annually. Ability to work alone in isolated areas, such as darkrooms. (Frequent) Additional New Requirements: Ability to obtain and maintain a valid drivers license. Computer literacy. Ability to work rotating shifts as required. Ability to work overtime as required. Ability to learn and use new processes, tools and equipment as required.If you like working with energetic enthusiastic individuals, you will enjoy your career with us!
The Medical University of South Carolina is an Equal Opportunity Employer. MUSC does not discriminate on the basis of race, color, religion or belief, age, sex, national origin, gender identity, sexual orientation, disability, protected veteran status, family or parental status, or any other status protected by state laws and/or federal regulations. All qualified applicants are encouraged to apply and will receive consideration for employment based upon applicable qualifications, merit and business need.
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