Job Description Summary
Seeking highly motivated individuals to work in the area of cellular signaling related to cancer development and progression. Candidates must have experience in molecular biology, biochemistry, and cell biology. Research in the laboratory is focused on two major areas: 1. Inhibition of RAS signaling and transformation; and 2. Role of the intersectin (ITSN) scaffold protein in oncogenic signaling. We have identified vulnerabilities in oncogenic RAS using novel biologics and are using these powerful tools to develop new therapeutic strategies to inhibit RAS-driven cancers (Spencer-Smith et al, Nat Chem Biol., doi: 10.1038/nchembio.2231; Khan et al Oncogene doi: 10.1038/s41388-018-0636-y; Khan et al, Small GTPases, dox: 10.1080/21541248.2021.1906621). Current studies are examining the importance of RAS dimerization/nanoclustering in activation of RAS effector pathways, using novel affinity reagents to probe isoform-specific differences in RAS signaling, and identification of small molecule RAS inhibitors. In addition, we are studying the role of the ITSN scaffold protein in regulating cellular signaling pathways involved in human cancers, in particular neuroblastoma (Herrero-Garcia, E. and O’Bryan,J.P., BBA-MRC, doi: 10.1016/j.bbamcr.2016.10.005; Russo, A. and O’Bryan, J.P., Oncogene, doi: 10.1038/onc.2011.643; Harris, J., et. al. J. Pediatr. Hematol. Oncol. doi: 10.1097/MPH.0000000000000931). Current projects center on ITSN’s role in regulating RAS family GTPases, lipid kinases, ubiquitin ligases, protein trafficking pathways, and the importance of these ITSN-regulated pathways in human disease, particularly cancer.
Applicants must have a Ph.D. or M.D. degree and be eligible for employment in the U.S. Preference will be given to candidates with strong skills in molecular biology, biochemistry, tissue culture, and animal work. These are non tenure-track positions, with renewal dependent on successful progress and continued funding. Start date is negotiable although preference will be given to candidates that can begin immediately. Salary range is commensurate with experience according to NIH scale for postdocs. Position is a benefit eligible position. For fullest consideration send electronic file containing statement of research interest and experience, curriculum vitae, and names of three references to: Dr. John P. O’Bryan, email: obryanjo@musc.edu. Applicants should also apply online at: http://careers.pageuppeople.com/756/cw/en-us/job/510339/univ-postdoctoral-scholar-pharmacology
Founded in 1824, The Medical University of South Carolina (MUSC) is now the core of the state’s largest medical complex and one of its largest employers with over 11,000 employees. Our research laboratory space exceeds 1 Million square feet. Extramural research funding awards to MUSC in 2017 exceeded $250 million. In addition, MUSC was named on Forbes first-ever list of America’s Best Employers for Diversity.
The Hollings Cancer Center (HCC) is the only NCI-Designated Cancer Center in South Carolina. Currently, HCC researchers hold approximately $45 Million in annual extramural cancer research funding with $23 Million originating from the NCI.
MUSC is located in historic Charleston, South Carolina. The weather is beautiful year-round, with temperatures rarely dropping below freezing during winter. There are several beaches within minutes of the city and the mountains are only three hours away. In addition to these amenities, the art, history, food, and festivals make Charleston an outstanding place to live.Entity
Medical University of South Carolina (MUSC - Univ)Worker Type
EmployeeWorker Sub-Type?
RegularCost Center
CC001034 COM PHARM Operations CCPay Rate Type
SalaryPay Grade
University-00
Pay Range
$0 - $0 - $0Scheduled Weekly Hours
40Work Shift
Job Description
Job Duties:
35% Develop an independent research project in consultation with the PI. Individual will be responsible for the design and implementation of experiments in the area of signaling transduction and cancer biology. Must maintain accurate and up to date laboratory records. Will be responsible for presenting result to PI in individual and group meetings.
35% Present work at local, regional, national and international meetings. Will be responsible for publication of results in leading scientific journals. Will work closely with PI to develop research grant proposals.
30% Will assist with daily maintenance of laboratory, training and supervision of technical staff, graduate students, and other laboratory personnel.
Minimum Requirements:
Ph.D., M.D. degree or equivalent
Additional Job Description
Physical Requirements: (Note: The following descriptions are applicable to this section: Continuous - 6-8 hours per shift; Frequent - 2-6 hours per shift; Infrequent - 0-2 hours per shift) Ability to perform job functions in an upright position. (Continuous) Ability to perform job functions in a seated position. (Continuous) Ability to perform job functions while walking/mobile. (Frequent) Ability to climb stairs. (Infrequent) Ability to work indoors. (Continuous) Ability to work in all cold temperature extremes, i.e. spot coolers. (Frequent) Ability to bend at the waist. (Frequent) Ability to twist at the waist. (Frequent) Ability to perform 'pinching' operations. (Continuous) Ability to fully use both hands/arms. (Continuous) Ability to perform repetitive motions with hands/wrists/elbows and shoulders. (Continuous) Ability to fully use both legs. (Continuous) Ability to reach in all directions. (Continuous) Possess good finger dexterity. (Continuous) Ability to maintain tactile sensory functions. (Continuous) Ability to maintain good olfactory sensory function. (Continuous) Ability to lift and carry 15 lbs., unassisted. (Frequent) Ability to lift objects, up to 15 lbs., from floor level to height of 72 inches, unassisted. (Frequent) Ability to lower objects, up to 15 lbs., from height of 72 inches to floor level, unassisted. (Frequent) Ability to push/pull objects, up to 15 lbs., unassisted. (Infrequent) Ability to lift and carry objects up to 15 lbs. a distance of five (5) floors and to outlying buildings. (Frequent) Ability to maintain 20/40 vision, corrected. (Continuous) Ability to see and recognize objects close at hand. (Continuous) Ability to see and recognize objects at a distance. (Continuous) Ability to match or discriminate between colors. (Continuous) Ability to determine distance/relationship between objects; depth perception. (Continuous) Good peripheral vision capabilities. (Continuous) Ability to maintain hearing acuity, with correction. (Continuous) Ability to perform gross motor functions with frequent fine motor movements. (Continuous) Ability to be qualified physically (by medical personnel) for respirator use, initially and annually. Ability to work alone in isolated areas, such as darkrooms. (Frequent) Additional New Requirements: Ability to obtain and maintain a valid drivers license. Computer literacy. Ability to work rotating shifts as required. Ability to work overtime as required. Ability to learn and use new processes, tools and equipment as required.If you like working with energetic enthusiastic individuals, you will enjoy your career with us!
The Medical University of South Carolina is an Equal Opportunity Employer. MUSC does not discriminate on the basis of race, color, religion or belief, age, sex, national origin, gender identity, sexual orientation, disability, protected veteran status, family or parental status, or any other status protected by state laws and/or federal regulations. All qualified applicants are encouraged to apply and will receive consideration for employment based upon applicable qualifications, merit and business need.
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